Structure-Function relationship of Transient Receptor Potential (TRP) ion channels in molecular complexes with homo-polymers
TRP channels play important roles in the perception of the environment. They respond to a number of physical and chemical stimuli and demonstrate an unusual complexity of regulatory modes.
The TRP family proteins are calcium-permeable channels and participate in a great variety of physiological and pathological processes. Physiological processes with involvement of TRP channels include thermosensation, nociception, mechanosensation, taste, vision, fertilization, intra- and extracellular Ca2+ and Mg2+ homeostasis.
Accumulated evidence also indicates involvement of TRP channels in pathophysiology and development of various diseases due to the multifunctional cellular responses carried by these proteins. Currently, we are interested in understanding the role of TRP channel in cancel cells. Expression of various TRP channels in different carcinogenic tissues has continually been reported, moreover some of the TRPs have originally been cloned from cancer cells. However, no clear mechanism of function of TRP channels and their roles in tumor-related regulations have immerged thus far. The role of TRP channels in processes like cell proliferation, differentiation, apoptosis, migration, and invasion upon cancer progression has yet to be understood.
Understanding the interplay of TRP channels and cancer cells is also critical at the level of molecular organization of these channels. It has become evident now that TRP channels are engaged in the molecular complexes, where their function can significantly be altered by the homo-polymers, like inorganic polyphosphate (polyP) and polyhydroxybutyrate (PHB).