Publications

PubMed Search

  1. L. McGoldrick, L. Demirkhanyan, A. Singh, T. Lin, R. Casner, E. Zakharian, and A. Sobolevsky. Structure of the Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas Reinhardtii. Nature Communications, in Press
  2. L. Mittermeier, L. Demirkhanyan, B. Stadlbauer, A. Breit, C. Recordati, A. Hilgendorff, M. Matsushita, A. Braun, D.G. Simmons, E. Zakharian, T. Gudermanna, and V. Chubanov. TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival. Proc Natl Acad Sci USA 2019 Feb 15. pii: 201810633. doi: 10.1073/pnas.1810633116.
  3. J. M. Arcas, A. González, K. Gers-Barlag, O. Gonzalez-Gonzalez, F. Bech, L. Demirkhanyan, E. Zakharian, C. Belmonte, A. Gomis, and F. Viana. The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels. In press at J. Neuroscience.
  4. Y. Nersesyan, L. Demirkhanyan, D. Cabezas-Bratesco, V. Oakes, R. Kusuda, T. Dawson, X. Sun, C. Cao, A. Cohen, B. Chelluboina, K. K. Veeravalli, K. Zimmermann, C. Domene, S. Brauchi, and E. Zakharian. Oxytocin modulates nociception as an agonist of pain-sensing TRPV1. Cell Reports, 21 (6):1681-1691, doi:10.1016/j.celrep.2017.10.063.
  5. S. Dembla, M. Behrendt, F. Mohr, C. Goecke, J. Sondermann, F.M. Schneider, M. Schmidt, J. Stab, R. Enzeroth, M.G. Leitner, P. Nuñez-Badinez, J. Schwenk, B. Nürnberg, A. Cohen, S.E. Philipp, W. Greffrath, M. Bünemann, D. Oliver, E. Zakharian, M. Schmidt, J. Oberwinkler. Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. eLife. 2017 Aug 15;6. pii: e26280. doi: 10.7554/eLife.26280. PMID: 28826482
  6. S. Asuthkar, L. Demirkhanyan, S.R. Mueting, A. Cohen, E. Zakharian. High-throughput proteome analysis reveals targeted TRPM8 degradation in prostate cancer. Oncotarget. 2016 Dec 26. doi: 10.18632/oncotarget.14178.
  7. P.A. Elustondo, M. Nichols, A. Negoda, A. Thirumaran, E. Zakharian, G.S. Robertson, E.V. Pavlov. Mitochondrial permeability transition pore induction is linked to formation of the complex of ATPase C-subunit, polyhydroxybutyrate and inorganic polyphosphate. Cell Death Discov. 2016 Dec 5;2:16070.
  8. M. E. Solesio, L. Demirkhanyan, E. Zakharian, E. V. Pavlov. Contribution of inorganic polyphosphate towards regulation of mitochondrial free calcium. Biochim Biophys Acta. 2016 June 1860(6):1317-25. doi: 10.1016/j.bbagen.2016.03.020. Epub 2016 Mar 16, PMID: 26994920
  9. L. Demirkhanyan, K. Uchida, A. Tominaga, E. Zakharian. TRPM3 gating in planar lipid bilayers defines peculiar agonist specificity. Channels (Austin) 2016 Feb 22:0, PMID: 26901668
  10. M. E. Solesio, P. A. Elustondo, E. Zakharian, E. V. Pavlov. Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore. Biochem Soc Trans. 2016 Feb 15;44(1):7-12. doi: 10.1042/BST20150206; PMID: 26862181.
  11. K. Uchida, L. Demirkhanyan, S. Asuthkar, A. Cohen, M. Tominaga, E. Zakharian. Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers. The FASEB Journal. 2015 Dec 9. pii: fj.15-281576, PMID: 26655382.
  12. S. Asuthkar, K. K. Velpula, P. Elustondo, L. Demirkhanyan, and E. Zakharian. TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells. Oncotarget, online ISSN: 1949-2553, PMID: 25980497.
  13. I. Bárcena-Uribarri, R. Benz, M. Winterhalter, E. Zakharian, N. Balashova. Pore forming activity of the potent RTX-toxin produced by pediatric pathogen Kingella kingae: Characterization and comparison to other RTX-family members. Biochim Biophys Acta. 2015 Apr 7; 1848(7): 1536-44, PMID: 25858109.
  14. X. Sun and E. Zakharian. Regulation of temperature-dependent activation of Transient Receptor Potential Vanilloid 1 by phospholipids in planar lipid bilayers. J Biol Chem. 2015 Feb 20; 290 (8): 4741-7, PMID: 25561742.
  15. S. Asuthkar, L. Demirkhanyan, X. Sun, P. Elustondo, V. Krishnan, P. Baskaran, K.K. Velpula, B. Thyagarajan, E. Pavlov, E. Zakharian. The TRPM8 protein is a testosterone receptor. Part II: Functional evidence for an ionotropic effect of testosterone on TRPM8. J Biol Chem. 2015 Jan 30; 290(5): 2670-88, PMID: 25480783.
  16. S. Asuthkar, P.A. Elustondo, L. Demirkhanyan, P. Baskaran, K. K. Velpula, B. Thyagarajan, E. Pavlov, E. Zakharian. The TRPM8 protein is a testosterone receptor. Part I: Biochemical evidence for direct TRPM8-testosterone interactions. J Biol Chem. 2015 Jan 30; 290(5): 2659-69, PMID: 25480785.
  17. D. Chang, Y. Nudell, J. Lau, E. Zakharian, N.V. Balashova. RTX-toxin plays a key role in Kingella kingae virulence in an infant rat model. Infect Immun. 2014 Jun; 82(6): 2318-28, PMID: 24664507.
  18. T. Zhuang, B. Chelluboina, S. Ponnala, K.K. Velpula, A.A. Rehman, C. Chetty, E. Zakharian, J.S. Rao, K.K. Veeravalli. Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration. BMC Cancer. 2013 Dec 11, 10.1186/1471-2407-13-590, PMID: 24325546.
  19. V. Lukacs, J.M. Rives, X. Sun, E. Zakharian, T. Rohacs. Promiscuous activation of transient receptor potential vanilloid 1 channels by negatively charged intracellular lipids, the key role of endogenous phosphoinositides in maintaining channel activity. J Biol Chem. 2013 Oct 24, PMID: 24158445.
  20. S. Prabhakar, S. Asuthkar, W. Lee, S. Chigurupati, E. Zakharian, A. J. Tsung, K. K. Velpula. Targeting DUSPs in Glioblastomas – Wielding a Double-edged Sword? Cell Biology Int. 2013 Oct 23, PMID: 24155099.
  21. C. Cao, Y. Yudin, Y. Bikard, W. Chen, T. Liu, H. Li, D. Jendrossek, A. Cohen, E. Pavlov, T. Rohacs, and E. Zakharian. Polyester modification of the mammalian TRPM8 channel protein: Implications for structure and function. Cell Reports, 2013 Jul 11, 4(2), 302-315, PMID: 23850286.
  22. M. Smithen, P. Elustondo, R. Winkfein, E. Zakharian, A. Abramov, and E. Pavlov. Role of polyhydroxybutyrate in mitochondrial calcium uptake. Cell Calcium, 2013 May 20, 54(2), 86-94, PMID: 23702223.
  23. C. Cao, E. Zakharian, I. Borbiro, T. Rohacs. Interplay between calmodulin and PI(4,5)P2 in Ca2+-induced inactivation of TRPV6. J Biol Chem. 2013 Jan 8, 288, 5278-5290, PMID: 23300090.
  24. P. Elustondo, E. Zakharian, and E. Pavlov. Identification of the polyhydroxybutyrate granules in mammalian cultured cells. Chemistry and Biodiversity, 2012 Nov, 9 (11): 2597-604. PMID: 23161637.
  25. E. Zakharian, C. Cao, T. Rohacs. Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2. FASEB J., 2011, v. 25 (11), 3915-3928. Highlighted in the “Life Science Weekly” newsletter.
  26. E. Zakharian, C. Cao, T. Rohacs. Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J. Neuroscience, 2010, v. 30 (37), 12526-34. Highlighted in the “This Week in the Journal” section and in the “Life Science Weekly” newsletter.
  27. E. Zakharian (corresponding author), B. Thyagarajan, R.J. French, E. Pavlov, and T. Rohacs. Inorganic polyphosphate modulates TRPM8 channels. PLoS One, 2009, v. 4, e5404.
  28. E. Zakharian, R.N. Reusch. Haemophilus Influenzae Outer Membrane Protein P5 is Associated with Inorganic Polyphosphate and Polyhydroxybutyrate. Biophys. J., 2007 v. 92 (2), 588-593. Highlighted in the “Life Science Weekly” newsletter.
  29. E. Zakharian, R.N. Reusch. Pore Characteristics of Nonetypeable Haemophilus Influenzae Outer Membrane Protein P5 in Planar Lipid Bilayers. Biophys. J., 2006, v. 91, 3242-3248. Highlighted the “Life Science Weekly” newsletter.
  30. E. Zakharian, R.N. Reusch. Kinetics of folding of E.coli OmpA from narrow to large pore conformation in a planar bilayer. Biochem., 2005, v. 44 (17), 6701-6707. Highlighted in the “Life Science Weekly”newsletter.
  31. E. Pavlov, E. Zakharian, C. Bladen, C. Diao, C. Grimbly, R. N. Reusch, and Robert J. French. A large, voltage-dependent channel, whose properties resemble the permeability transition pore, isolated from mitochondria. Biophys. J., 2005, v. 88, 2614-2625.
  32. E. Zakharian, R.N. Reusch. Functional evidence for a supramolecular structure for the Streptomyces lividans potassium channel KcsA. BBRC, 2004, v. 322, 1059-1065.
  33. E. Zakharian, R.N. Reusch. Streptomyces lividans KcsA channels are regulated by the potassium electrochemical gradient. BBRC, 2004, v. 316, 429-436.
  34. E. Zakharian, R.N. Reusch. Outer membrane protein A of Escherichia coli forms temperature-sensitive channels in planar bilayers. FEBS Letters, 2003, v.555, 229-235.
  35. Akopian K., Zakharian E., Kirakosyan G., Mnatsakanyan N., Bagramyan K. and Trchounian A. Interaction of membrane proton conductivity, membrane and oxidation-reduction potential in Escherichia coli /Biophysics 2002, v. 47, 1064-1067.
  36. Mnatsakanyan N., Zakharyan E., Bagramyan K., Trchounian A. Dithiol-disulphide interchanges in membrane transporting proteins on Escherichia coli. Biol. Membrany., 2002, v.19, N21, 181-190.
  37. E. Zakharyan and A. Trchounian. K+ influx by Kup in Escherichia coli is accompanied by a decrease in H+efflux. FEMS Microbiol. Lett., 2001, v.204, 61-64.
  38. Mnatsakanyan N., Zakharyan E., Poladyan A., Bagramyan K., Trchounian A. Dithiol-disulphide interchange in operation of the F0F1-ATPase in fermenting bacteria. EBEC Reports, 2000, v.11, 90-96.
  39. Mnatsakanyan N., Zakharyan E., Poladyan A., Vassilian A., Bagramyan K., Trchounian A., Nakamoto R. The Escherichia coli F0F1 ATP synthase under fermentation: Cysb21Ala replacement perturbs K+ uptake and H2 production. Eur. Biophys. J., 2000, v.29, 328-334.
  40. E. Zakharyan, E. Ogandjanian, and A. Trchounian. Regulation of Intracellular pH and Proton-Potassium Exchange in Fermenting Escherichia coli Grown Anaerobically in Alkaline Medium. // Membr. Cell Biol., 1998, v.15, 56-65.
  41. Trchounian A.A., Ogandjanian E.S., Bagramyan K.A., Vardanian V.A., Zakharian E.G., Vassilian A.V., Davtian M.A. Relationship of the E.coli TrkA system of potassium ion uptake with the F0F1-ATPase under growth conditions without anaerobic or aerobic respiration. // Biosci. Rep., 1998, v.18, 143-154.
  42. Zakharian E.G, Bagramyan K.A., Ogandjanian E.S., Vassilian A.V., and Trchounian A.A. An electrochemical study of energy-dependent potassium accumulation in E.coli. Part XIV. Comparison of K+ uptake characteristics in anaerobically grown cells, performing glycolysis or nitrate-nitrite respiratory chain. Bioelectrochem. Bioenerg. 1996, v.39, 13-19.

Book Chapters

  1. Eleonora Zakharian: “TRP channel reconstitution in lipid bilayers ” Book title: TRP Channels: Editors: Antonio Ferrer-Montiel and Tim Hucho, the Methods in Molecular Biology (MIMB) 1987, 143-166, 2019; doi: 10.1007/978-1-4939-9446-5_10.
  2. Eleonora Zakharian: “Inorganic polyphosphate is essential component of ion channel complexes”. Book title: “Diverse Functions of Polyphosphates in Eukaryotic Cells.” Editor Tatiana Kulakovskaya et al. Springer International Publishing Switzerland 2016, Inorganic Polyphosphates in Eukaryotic Cells, DOI 10.1007/978-3-319-41073-9_13.
  3. Tong Liu, Wei Chen, Hong Li, and Eleonora Zakharian: “Determination of polyhydroxybutyrate (PHB) post-translational modifications of proteins using mass spectrometry.” Book title: Analysis of Post-Translational Modifications and Proteolysis in Neuroscience. Editors, Jennifer Grant and Hong Li: Publisher: Humana Press. Editors, Jennifer Grant and Hong Li. DOI: 10.1007/7657_2015_86.
  4. Eleonora Zakharian: “Recording of ion channel activity in planar lipid bilayers experiments.” Book title: Ion Channels (2nd Edition): Editor Nikita Gamper, Methods Mol Biol 998, 109-118. DOI: 10.1007/978-1-62703-351-0_8

Abstracts/Presentations

  1. B. Thyagarajan and E. Zakharian. TRPM8 regulates sexual reward and satiety. The 23rd Annual Meeting of the Society for Behavioral Neuroendocrinology, June 2019.
  2. Y. Nersesyan, E. Gribkova, P. Baskaran, D. Llano, B. Thyagarajan, E. Zakharian. TRPM8 regulates sexual desire and satiety. Biophysical Journal, 63d Annual Biophysical Meeting, March 2019.
  3. P.N. Thai, L. Demirkhanyan, M. Todd King, E. Zakharian, R. Veech, S. Schaefer, D.M. Bers, E.N. Dedkova. Ketone Bodies and their Polymers in Heart Failure and Type 2 Diabetes: Lessons Learned from the Ketone Ester Diet. Biophysical Journal, 63d Annual Biophysical Meeting, March 2019.
  4. L. Demirkhanyan, D. Gao, E. Zakharian. PHB regulates trafficking of TRPM8 to the plasma membrane. Biophysical Journal, 63d Annual Biophysical Meeting, March 2019.
  5. L. Demirkhanyan, V. Vivek, S. Asuthkar, B. Alexander, Z. Hussain, P. Baskaran, Y. Nersesyan, A. Cohen, E. Pavlov, B. Thyagarajan, E. Zakharian. TRPM8 regulates sexual desire and satiety. Biophysical Journal, 62nd Annual Biophysical Meeting, Volume: 114, Issue: 3, Supplement: 1, p643a; DOI: 10.1016/j.bpj.2017.11.3469, February 2018.
  6. Y. Nersesyan, L. Demirkhanyan, D. Cabezas-Bratesco, V. Oakes, R. Kusuda, T. Dawson, X. Sun, C. Cao, A. Cohen, B. Chelluboina, K. K. Veeravalli, K. Zimmermann, C. Domene, S. Brauchi, and E. Zakharian. Oxytocin modulates nociception as an agonist of pain-sensing TRPV1. Biophysical Journal, 62nd Annual Biophysical Meeting, Volume: 114, Issue: 3, Supplement: 1, p396a; DOI: 10.1016/j.bpj.2017.11.2192, February 2018.
  7. G. F. Amodeo, N. Mnatsakanyan, M. E. Solesio, M. Klim, P. Kurcok, E. Zakharian, E. A. Jonas, E. V. Pavlov. Molecular assembly of the mitochondrial Permeability Transition Pore. Biophysical Journal, 62nd Annual Biophysical Meeting, Volume: 114, Issue: 3, Supplement: 1, p658a; DOI: 10.1016/j.bpj.2017.11.3554, February 2018.
  8. Y. Nersesyan, L. Demirkhanyan, T. Dawson, S. Asuthkar, D. Cabezas-Bratesco, S. Brauchi, E. Zakharian. Crosstalk of pain and pleasure: TRPV1 is a novel oxytocin receptor. Biophysical Journal, 61st Annual Biophysical Meeting, New Orleans, February 2017.
  9. L. Demirkhanyan, T. Dawson, T. Gudermann, V. Chubanov, E. Zakharian. Assessment of endogenous and exogenousmodulators of the TRPM7 channel in planar lipid bilayers. Biophysical Journal, 61st Annual Biophysical Meeting, New Orleans, February 2017.
  10. S. Asuthkar and E. Zakharian. TRPM8 is avidly targeted for degradation in prostate cancer. Cancer Research, Volume: 76 Supplement: 14 Meeting Abstract: 1165; DOI: 10.1158/1538-7445.AM2016-1165, ISSN: 0008-5472, July 2016.
  11. L. Demirkhanyan, K. Uchida, S. Asuthkar, A. Cohen, M. Tominaga, E. Zakharian. TRPM3 exhibits slight temperature sensitivity in the planar lipid bilayer system and requires the presence of PIP2. Biophysical Journal, Volume: 110 Issue: 3 Pages: 612A-612A, Meeting Abstract: 3023-Pos, ISSN: 0006-3495, 60th Annual Biophysical Meeting, Los Angeles, February 2016.
  12. S. Asuthkar, A. Cohen, L. Demirkhanyan, E. Zakharian. Ubiquitin-mediated TRPM8 protein degradation in the pathogenesis of prostate cancer. Biophysical Journal, Volume: 110 Issue: 3 Pages: 613A-613A, Meeting Abstract: 3026-Pos, ISSN: 0006-3495, 60th Annual Biophysical Meeting, Los Angeles, February 2016.
  13. Z. Hussain, L. Demirkhanyan, S. Asuthkar, E. Zakharian. Testosterone is a highly potent and specific agonist of TRPM8. Biophysical Journal, Volume: 110 Issue: 3 Pages: 613A-613A, Meeting Abstract: 3025-Pos, ISSN: 0006-3495, 60th Annual Biophysical Meeting, Los Angeles, February 2016.
  14. L. Demirkhanyan, I. P. Palmer, W. Boyd, C. S. Sondergaard, K. Grimsrud, L. G. Griffiths, J. Bossuyt, D. M. Bers, E. Zakharian, E. N. Dedkova. Formation of polyphosphate-poly-beta-hydroxybutyrate granule-like complexes in heart failure myocytes. Biophysical Journal, Volume: 110 Issue: 3 Pages: 310A-311A, Meeting Abstract: 1525-Pos, 60th Annual Biophysical Meeting, Los Angeles, February 2016.
  15. M. E. Solesio Torregrosa, L. Demirkhanyan, E. Zakharian, E. Pavlov. Contribution of inorganic polyphosphate towards regulation of mitochondrial free calcium. Biophysical Journal, volume: 110 issue: 3 pages: 310A-310A, Meeting Abstract: 1524-Pos, 60th Annual Biophysical Meeting, Los Angeles, February 2016.
  16. S. Asuthkar and E. Zakharian. Androgen-mediated genomic and non-genomic regulation of TRPM8 in prostate cancer. Cancer Research, Volume: 75 Supplement: 15 Meeting Abstract: 5005, DOI: 10.1158/1538-7445.AM2015-5005, ISSN: 0008-5472, August 2015.
  17. S. Asuthkar, L. Demirkhanyan, X. Sun, P. Elustondo, V. Krishnan, P. Baskaran, K. K. Velpula, B. Thyagarajan, E. Pavlov, E. Zakharian. TRPM8 is an ionotropic testosterone receptor. Biophysical Journal, Volume: 108 Issue: 2 Pages: 38A-38A, Meeting Abstract: 184-Plat, ISSN: 0006-3495, 59th Annual Biophysical Meeting, Baltimore, MA, February 2015.
  18. S. Asuthkar, K. K. Velpula, P. Elustondo, L. Demirkhanyan, E. Zakharian. The plasma membrane TRPM8 plays a protective role against prostate cancer progression; trmp8 gene as a downstream target of p53 tumor-suppressor. Biophysical Journal, Volume: 108 Issue: 2 Pages: 284A-284A Supplement: 1 Meeting Abstract: 1423-Pos, ISSN: 0006-3495, 59th Annual Biophysical Meeting, Baltimore, February 2015.
  19. L. Demirkhanyan, K. Uchida, E. Zakharian. Regulation of the TRPM3 channel in planar lipid bilayers. Biophysical Journal, Volume: 108 Issue: 2 Pages: 283A-283A Supplement: 1 Meeting Abstract: 1418-Pos, ISSN: 0006-3495, 59th Annual Biophysical Meeting, Baltimore, February 2015.
  20. Y. Nersesyan, S. Asuthkar, K. K. Velpula, X. Sun, L. Demirkhanyan, E. Zakharian. Role of TRPV1 channels in glioma cell viability and survival. Biophysical Journal, Volume: 108 Issue: 2 Pages: 124A-124A, Meeting Abstract: 618-Pos, 59th Annual Biophysical Meeting, Baltimore, February 2015.
  21. S. Asuthkar, K. K. Velpula, E. Zakharian. TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells. Cancer Research, Volume: 74 Issue: 19 Supplement: S Meeting Abstract: 615, DOI: 10.1158/1538-7445.AM2014-615, ISSN: 0008-5472, October 2014.
  22. X. Sun and E. Zakharian. PI(4,5)P2 positively regulates transient receptor potential vanilloid 1 channel activation in planar lipid bilayers. Biophysical Journal, Volume: 106 Issue: 2 Pages: 335A-335A Supplement: 1, ISSN: 0006-3495, January 2014.
  23. S. Asuthkar, L. Demirkhanyan, X. Sun, P. Elustondo, K. Velpula, E. Pavlov, E. Zakharian. Regulation of TRPM8 channel activity in prostate cancer by androgens. Biophysical Journal, Volume: 106 Issue: 2 Pages: 334A-335A Supplement: 1, ISSN: 0006-3495, January 2014.
  24. J-M. Rives, V. Lukacs, X. Sun, E. Zakharian, T. Rohacs. Regulation of TRPV1 by phosphoinositides and other negatively charged lipids. Biophysical Journal, Volume: 106 Issue: 2 Pages: 334A-335A Supplement: 1, ISSN: 0006-3495, 2014, 106(2), p. 757a.
  25. L. Demirkhanyan, P. Elustondo, E. Pavlov, E. Zakharian. Role of polyphosphate in cancer cell proliferation. Biophysical Journal, Volume: 106 Issue: 2 Pages: 753A-753A Supplement: 1, ISSN: 0006-3495, January 2014.
  26. Y.Bikard, and E. Zakharian. PHBylation sites of the TRPM8 protein: implications to the channel structure and function. Biophysical Journal, 2013, 104(2), p. 456a.
  27. P. Pal, M. A. Poquette, M. G. Keehan, B. Zepada, E. Zakharian, A. L. Escobar, and G. A. Barrall. Detection of Trpm8 and RyR2 Activity on a Low-Noise, Automated Planar Lipid Bilayer Platform. Biophysical Journal, 2013, 104(2), p. 630a.
  28. C. Cao, E. Zakharian, I. Borbiro, T. Rohacs. The roles of calmodulin and PI(4, 5)P2 in Ca2+-induced inactivation of TRPV6 channels. Biophysical J., 2013, 104(2), p. 457a.
  29. M. Smithen, P. Elustondo, R. Winkfein, E. Zakharian, A. Abramov, and E. Pavlov. Role of polyhydroxybutyrate in mitochondrial calcium transport. Mitochondrial Physiology and Medicine, Society of General Physiology V. 102, Issue 3, Sup. 1, 31 January 2012, p. 165a.
  30. C. Cao, Y. Yudin, W. Chen, H. Li, E. Pavlov, T. Rohacs, and E. Zakharian. Polyhydroxybutyrate (PHB) is an essential structural compound of TRPM8 channel required for its function. Biophysical Journal, V. 102, Issue 3, Sup. 1, 31 January 2012, p. 344a.
  31. E. Zakharian, C. Cao, T. Rohacs. Molecular mechanisms of calmodulin regulation of TRPV6. Biophysical Journal, V. 102, Issue 3, Sup. 1, 31 January 2012, p. 343a.
  32. E. Zakharian, E. Pavlov, C. Cao, T. Rohacs. Endogenous polyhydroxybutyrate (PHB) regulates TRPM8 channel. Biophysical Journal, V. 100, Issue 3, Sup. 1, 2 February 2011, p. 109a.
  33. E. Zakharian, C. Cao, T. Rohacs. Direct activation of TRPV6 channels by phosphatidylinositol 4,5-bisphosphate. Biophysical Journal, V. 100, Issue 3, Sup. 1, 2 February 2011, p. 107a.
  34. E. Zakharian, T. Rohacs. Phosphoinositide regulation of TRPM8 channels in Planar Lipid Bilayers. Biophysical Journal, V. 98, Issue 3, Sup. 1, January 2010, p. 227a–228a.
  35. E. Zakharian, and T. Rohacs. Channel properties of TRPM8 in supramolecular complex with inorganic polyphosphate and polyhydroxybutyrate. Biophysical Journal, 96-3, Sup. 1, 265A, 2009.
  36. E. Zakharian, B. Thyagarajan, R.J. French, E. Pavlov, and T. Rohacs. Transient Receptor Potential channel TRPM8 is associated with Polyphosphate and Polyhydroxybutyrate. Biophysical Journal, Volume 94: 3050, 2008.
  37. E. Zakharian, T. Rohacs. Phosphoinositide regulation of transient receptor potential channel TRPM8 reconstituted into planar lipid bilayer. Biophysical Journal, 289a-290a January 2007.
  38. R.N. Reusch, E. Zakharian. Haemophilus Influenzae Outer Membrane Protein P5 is Associated with Inorganic Polyphosphate and Polyhydroxybutyrate. Biophysical Journal, 72A-73A Jan, 2007.
  39. E. Zakharian, R.N. Reusch. Functional evidence for a supramolecular structure for the Streptomyces lividans potassium channel KcsA. Biophysical Journal, 88 (1) 458A January 2005.
  40. E. Pavlov, E. Zakharian, C. Bladen, C. Diao, C. Grimbly, R. N. Reusch, and Robert J. French. A chloroform extract of dehydrated mitochondrial membranes contains a channel whose properties resemble the permeability transition pore. Biophysical Journal, 88 (1) 177A Jan, 2005.
  41. E. Zakharian, R.N. Reusch. Outer membrane protein A of Escherichia coli forms temperature-sensitive channels in planar bilayers. Biophysical Journal, 86 (1) 467A Jan, 2004.
  42. K. Bagramyan, K. Hakobyan, E. Zakharyan, G. Kirakosyan, N. Mnatsakanyan, A. Trchounian. Relation of Escherichia coli membrane: proton conductivity with membrane and redox potential. 12th European Bioenergetics Conference, Arcachon, September 9-14 2002.
  43. E. Zakharian and A. Trchounian. Escherichia coli Kup operates as a H+-K+-symporter. “Mitochondria in the Cell Life and Death” FEBS symposia, September 2-7 2001, Moscow State University, Moscow, Russia, p. 28.
  44. K. Baghramyan, N. Mnatsakanyan, E. Zakharyan, A. Poladyan, R. Nakamoto, A. Trchounian. The role of cysteine residues in the action of F0F1 ATPase of Escherichia coli and its interaction with membrane transport proteins and anaerobic enzymes for oxidation and reduction processes. “Problems of Biochemistry, Radiation and Space Biology”, 2nd International symposium under the auspices of UNESCO dedicated to the memory of academician N. Sissakian. Moscow, Dubna, May 29 – June 1. 2001. p. 62.
  45. E. Zakharyan and A. Trchounian. Escherichia coli Kup operates as a H+-K+-symporter. 27th Meeting of the Federation of European Biochemical Societies, Lisbon, Portugal, 2001, v.268, s.1, PW11-039.
  46. Zakharyan E. and Trchounian A. Escherichia coli uses a distinct K+ uptake system and/or a different mode in its operating depended on grown pH. 18th Intern. Congress on Biochemistry and Mol. Biology “Beyond the Genome”, Abstract, Birmingham, UK, 2000, p.14-24.
  47. Trchounian A.A., Ogandjanian E.S., Bagramyan K.A., Vassilian A.V., and Zakharian E.G. Growth physico-chemical conditions control interaction between primary and secondary ion-transporting membrane systems in bacteria. Biothermokinetics of the Living Cell, p.445-448, ed. by H. Westerhoff, Amsterdam, Nederland: BioThermoKinetics Press, 1996.