Shao-yu Chen, PhD   

Associate Professor, Department of Cancer Biology & Pharmacology
University of Illinois College of Medicine at Peoria (UICOM-P), Peoria IL
 
Contact me:      E-mail:     sychen@uic.edu
                        Phone:    309-671-8538  
                        Mail:        University of Illinois College of Medicine at Peoria 
                                        Department of Cancer Biology & Pharmacology 
                                        P.O. Box 1649, Peoria, IL 61656-1649

 
Education/Training
1993 -1998     Postdoctoral training. Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill
1991 Ph.D., Biochemistry, Fujian Agricultural and Forest University, China
 
Positions Held
2010-Present Associate Professor (Tenured), Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL
2009-2010 Associate Professor, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL
2004-2009 Associate Professor, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC
1998-2004 Assistant Professor, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC
 

 

Current Grants and Contract Support

NIH/NIAAA RO1 AA017446  “Role of Nrf2 Signaling in Modulating Ethanol-induced Teratogenesis” PI: Shao-yu Chen. 2008-2013, Total Direct Costs $1,012,500. (Total Costs $1,569.426).

NIH/NIAAA RO1 AA020265 “Role of Siah1 in Ethanol-induced Apoptosis and Teratogenesis” PI: Shao-yu Chen. 2012-2017. Total Direct Costs $1,106,250 (Total Costs $1,736,815)

Research

My research interests are directed toward achieving a better understanding of the cellular and molecular mechanisms associated with ethanol-induced apoptosis and birth defects. Major research directions in my laboratory include oxidative stress, apoptosis, gene regulation and signal transduction. A combination of state-of-the-art approaches, including quantitative real-time PCR, RNA interference, microRNA technology and ultrasound-guide in utero microinjection, are integrated with cell and whole embryo culture systems, as well as in vivo mouse models of Fetal Alcohol Spectrum Disorders (FASD) to elucidate the molecular mechanisms underlying ethanol-induced birth defects. The findings from these studies may offer new strategies for development of preventative/ameliorative measures for FASD.

Selected Publications    Total:  36 publications,  29 abstracts

1. Chen S.-Y., Wilkemeyer M.F., Sulik K.K., Charness M.E. Octanol antagonism of ethanol teratogenesis. FASEB Journal 15:1649-1651, 2001.

2. Wilkemeyer M.F.*, Chen S.-Y.*, Menkari C.E., Brenneman D.E., Sulik K.K., Charness M.E. Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity. Proceedings of the National Academy of Sciences of the USA  100: 8543-8548, 2003 (*co-first authors).

3. Chen S.-Y., Dehart D.B., Sulik K.K. Protection from ethanol-induced limb malformations by the superoxide dismutase/catalase mimetic, EUK-134, FASEB J. 18: 1234-1236, 2004.

4. Chen S.-Y., Charness M.E., Wilkemeyer M.F., Sulik K.K. Peptide-mediated protection from ethanol-induced neural tube defects. Dev Neurosci. 27(1):13-19, 2005.

5. Dong J., Sulik K.K., Chen S.-Y. Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: Implications for the prevention of fetal alcohol spectrum disorders. Antioxidants & Redox Signaling. 10: 2023-2033, 2008.

6. Dong J, Sulik KK, Chen SY. The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. Toxicol Lett. 193(1):94-100, 2010

7. Yan D, Dong J, Sulik KK, Chen S.-Y. Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells. Biochem Pharmacol. 80(1):144-9, 2010.

8. Parnell SE, Dehart DE, Sulik KK, Chen S-Y. Reduction of ethanol-induced ocular abnormalities in mice via dietary administration of N-acetylcysteine. Alcohol 44: 699-705 2010.

9.  Zhang Q, Ma Y, Cheng Y-F, Li W-J, Zhang ZZ, Chen S-Y. Involvement of reactive oxygen species in 2- methoxyestradiol-induced apoptosis in human neuroblastoma cells. Cancer Letters 313: 201 - 210, 2011.

10. Chen S.-Y. Analysis of Nrf2-mediated transcriptional induction of antioxidant response in early embryos.  Methods Mol Biol. 888:277-290, 2012